Polynucleotide therapy — commonly known as PDRN treatment — has become one of the most talked-about treatments in aesthetic medicine, and for good reason. Backed by decades of clinical research and used extensively in regenerative medicine, PDRN delivers genuine, measurable skin renewal that goes far beyond surface-level hydration.
At Skin Health Practice, PDRN is a cornerstone of our regenerative treatment philosophy. We use it across several of our specialist protocols and as a standalone treatment for clients seeking significant skin improvement.
What Is PDRN?
PDRN stands for polydeoxyribonucleotide — long chains of DNA fragments derived from salmon sperm cells (a source that has been safely used in clinical medicine for decades). These DNA fragments are highly biocompatible with human tissue and act as a scaffold and stimulus for cellular regeneration.
When introduced into the skin, PDRN works through two primary mechanisms:
**1. Tissue repair activation** — PDRN binds to A2A receptors on skin cells, activating pathways that stimulate fibroblast activity. Fibroblasts are the cells responsible for producing collagen, elastin, and hyaluronic acid — the structural proteins that keep skin firm, elastic, and hydrated.
**2. DNA salvage pathway** — The DNA fragments in PDRN provide a direct source of nucleotides that skin cells can use to repair damaged DNA and accelerate their own renewal. This is particularly valuable in ageing or sun-damaged skin where cellular repair mechanisms have slowed.
What Can PDRN Treat?
PDRN is remarkably versatile and effective across a wide range of skin concerns:
- **Dehydrated, dull skin** — PDRN stimulates the skin's own hyaluronic acid production for deep, lasting hydration - **Fine lines and early wrinkles** — collagen and elastin stimulation restores plumpness and elasticity - **Thinning skin** — rebuilds the dermis from within, improving thickness and resilience - **Acne scars** — tissue repair and remodelling gradually softens scarring - **Sun damage** — supports repair of UV-damaged cells - **Post-procedure recovery** — used to accelerate healing after laser or microneedling treatments - **Under-eye hollowing and dark circles** — when used in the delicate periorbital area
Treatment Options at Skin Health Practice
We offer PDRN as both a standalone injectable treatment and as part of our advanced microneedling protocols (where it is applied topically through micro-channels for deeper penetration without needles).
**As an injectable:** PDRN is administered using a fine needle in a series of small intradermal injections across the treatment area. The technique is similar to skin boosters but with a fundamentally different mechanism of action — PDRN doesn't add volume, it stimulates your own skin to regenerate.
**Via microneedling:** For clients who prefer a needle-free approach, PDRN serum applied during professional microneedling reaches the dermis effectively through the micro-channels created by the device.
What Results Can You Expect?
Most clients notice improved skin quality — better hydration, smoother texture, and a more radiant complexion — within 2–3 weeks of their first session as the regenerative process begins.
Collagen and elastin improvements build progressively over 3–6 months. A typical course of 3–4 sessions is recommended, spaced 3–4 weeks apart, followed by maintenance every 3–6 months.
Unlike dermal fillers, PDRN does not add artificial volume — it restores the skin's own structural integrity. Results look natural because they are natural.
Is PDRN Treatment Right for You?
PDRN is suitable for most skin types and is particularly well-suited to:
- Clients in their 30s and above with early to moderate signs of ageing - Anyone with chronic skin dehydration that topical products aren't addressing - Those recovering from acne or with residual scarring - Clients who prefer a biological, non-synthetic approach to skin renewal
We currently offer **up to 30% off** PDRN treatment packages. Book your free consultation at Skin Health Practice — call **020 3886 1313** or visit 65-73 Staines Road, Hounslow, TW3 3HW.