Polynucleotide (PDRN) Treatment
Polynucleotide (PDRN) treatment is one of the most advanced biostimulating therapies available in aesthetic medicine today. Derived from highly purified salmon DNA, polynucleotides work at a cellular level to repair damaged tissue, stimulate the production of new collagen and elastin, and deeply hydrate the skin from within. Unlike traditional skin boosters that simply add volume or moisture, PDRN actively triggers the skin's own regenerative mechanisms — making it a powerful solution for ageing skin, scarring, dark circles, and overall skin quality.
Reviewed by Su Rixon · Aesthetic Clinician · Last reviewed April 2026
What Are Polynucleotides?
Polynucleotides are long chains of nucleotides — the building blocks of DNA. In aesthetic medicine, highly purified PDRN (Polydeoxyribonucleotide) derived from salmon DNA is used due to its exceptional biocompatibility with human tissue. When injected into the skin, polynucleotides stimulate fibroblast activity, accelerate tissue repair, promote angiogenesis (new blood vessel formation), and trigger the synthesis of collagen and hyaluronic acid. The result is a genuine biological improvement in skin quality rather than a temporary cosmetic fix.
What Can PDRN Treat?
Polynucleotide treatment is highly versatile and effective across a broad range of concerns. It is particularly powerful for improving skin hydration and radiance, reducing fine lines and wrinkles, improving skin laxity and firmness, treating acne scars and post-inflammatory marks, brightening dark circles and under-eye hollowness, and restoring dull or tired-looking skin. It is also used on the neck, décolletage, and hands to address signs of ageing in these delicate areas.
The Treatment Process
A topical numbing cream is applied before treatment to ensure your comfort. The PDRN solution is then administered through a series of small injections across the treatment area using a fine needle or cannula. The technique is precise and targeted, delivering the polynucleotides exactly where the skin needs support. Sessions typically take 30–45 minutes. A course of 3–4 treatments spaced 2–4 weeks apart is typically recommended for optimal results, followed by maintenance sessions every 4–6 months.
Results and What to Expect
Polynucleotide treatment produces gradual, natural-looking results as the skin's repair and regeneration processes are activated. Many clients notice improved hydration, plumpness, and a healthy glow within 2–3 weeks of their first session. Improvements in skin texture, firmness, and fine lines become more significant after a course of treatments, with results continuing to develop for several weeks following the final session. As a biostimulator, PDRN produces results that improve with time rather than providing an instant volumising effect.
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Why Choose This Treatment
Key Benefits
Repairs and regenerates skin
Repairs and regenerates skin at a cellular level
Stimulates natural collagen and
Stimulates natural collagen and elastin production
Deeply hydrates and restores
Deeply hydrates and restores skin radiance
Effective for fine lines
Effective for fine lines, dark circles, and acne scars
Natural
Natural, gradual results with no artificial fillers
Suitable for face
Suitable for face, neck, décolletage, and hands
Frequently Asked Questions
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Regenerate Your Skin From Within
Book a free consultation at Skin Health Practice to find out how Polynucleotide treatment can restore your skin's health, radiance, and youthfulness from the inside out.